http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111333667-B
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D517-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D517-06 |
filingDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-111333667-B |
titleOfInvention | Selenium-containing heterocyclic naphthalimide derivative and preparation method and antiviral application thereof |
abstract | The invention discloses a naphthalimide derivative containing selenium heterocycle, a preparation method and antiviral application thereof, wherein the naphthalimide derivative is 1 H ,3 H Selenium xantheno [2,1,9- def ]Isoquinoline-1, 3 (2) H ) -a diketone derivative hydrochloride having the structural formula shown in any one of formulas (1-7): . The compounds 1-7 of the invention are used for acting with guanine-rich DNA sequences in the promoter region of the human host cell type II serine protease TMPRSS2 to induce the formation of G-quadruplexes; thereby inhibiting the proliferation of influenza virus and coronavirus and achieving the aim of antivirus. Computer molecular simulation experiments show that the conjugated parent ring structure in the compounds 1-7 can interact with a G-tetrad formed in a research target in a pi-pi accumulation mode, and a side chain can be well combined with a groove structure of the G-tetrad. The invention plays an important role in promoting the research and development of clinical drugs of the selenium-containing heterocyclic naphthalimide derivative, and especially has important value in finding new antiviral micromolecular drugs. |
priorityDate | 2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 896.