http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111269261-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ed53d42b0f2da7049ebb4fb6cbeb905 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-70 |
| filingDate | 2020-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaff02e9ccdfa3320240b4cbb473b94e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_011ea9361b62fc0c9ff3c1fe20b27b18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6901c5c3227295988ffe16c2c43322c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4654caee4cb85a0b7de2be650fcf4a58 |
| publicationDate | 2020-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111269261-A |
| titleOfInvention | Liquid-phase total synthesis of TSBP auxiliary groups and group-assisted enkephalins and their derivatives |
| abstract | The present invention relates to a liquid phase total synthesis method of TSBP auxiliary group and group-assisted enkephalin and derivatives thereof. OH, Xaa is the C-terminal connection of any amino acid), then through separation and purification, removal of N-terminal PG, polypeptide coupling, the corresponding amino acid is repeatedly coupled, and the amino acid sequence of enkephalin or its derivative precursor is constructed H 2 N-Tyr(OtBu)-Gly-Gly-Phe-Xaa-TSBP; through deprotection of the side chain, separation and purification of enkephalin and its derivatives, to obtain enkephalin and its derivatives H 2 N-Tyr ‑Gly‑Gly‑Phe‑Xaa‑ZH (Z=O, S, NH, etc.). Compared with the existing synthesis methods, the present invention has the advantages of both liquid phase and solid phase synthesis methods, and can synthesize and prepare glutathione more simply, quickly, economically and efficiently, and the phosphate ester carrier can be recovered and directly. Reuse, reduce waste of raw materials, reduce waste pollution, save costs, and be conducive to environmental protection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112175002-A |
| priorityDate | 2020-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.