| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_553a717e2044255d07ffb86bdaf3bcd6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-223
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-221
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0041 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2020-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_776378bdb590250a6a94c15fa0dd0339
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16564e997bb5ff0a0ba34a59d1ef98e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d0101d16da8fbcb5ef092aced9caf53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d10764e69a6e63722ef1fbd378521ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c5d42f63ecb513b4a60e11a80e8dd53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ab96b548333ab49672ec0376f0c4481
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b9ccfbf3cc3e46d60452c30aed129a0 |
| publicationDate |
2020-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-111249471-A |
| titleOfInvention |
A kind of preparation method of polyethylenimine nanoparticle microbubble complex for gene delivery |
| abstract |
The invention discloses a preparation method of a polyethylenimine nanoparticle microbubble complex for gene delivery, comprising the steps of: preparing biotinylated lipid microbubbles; preparing avidinylated lipid microbubbles; preparing biotinylated lipid microbubbles PEG-SS-PEI nanoparticles; preparation of polyethylene glycol-polyethyleneimine nanoparticle-microbubble composites. The advantages of the invention are as follows: the lipid microbubbles are coupled with the polyethylene glycol-polyethyleneimine nanoparticles by the biotin-avidin method to prepare a polyethylene glycol-polyethyleneimine nanoparticle The microbubble complex not only makes up for the deficiency of lipid microbubbles as gene carriers for carrying genes, but also solves the shortcoming of poor targeting ability of polyethylene glycol-polyethyleneimine nanoparticles. |
| priorityDate |
2020-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |