| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df6a96d0349ae97fbe10332d41282c91 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0047
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0091 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb001166a1c363f109876510b4c220af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d06943ec332012ac5632fa71b79793d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36bb702abd5eb4977d638710731956e8 |
| publicationDate |
2019-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-110237268-A |
| titleOfInvention |
A preparation method of dual-response liposome microbubble complex loaded with doxorubicin |
| abstract |
The present invention relates to a preparation method of a dual-response liposome microbubble complex loaded with doxorubicin, which comprises the following steps: (1) reacting DSPE‑PEG2000‑NHS with cRGD to obtain DSPE‑PEG2000‑cRGD; (2) hydration reaction of DPPC, MSPC, DSPE‑PEG2000‑cRGD and DSPE‑PEG2000‑Biotin to obtain targeted thermosensitive liposome nanoparticles carrying cRGD peptide; (3) use targeted thermosensitive lipid The doxorubicin-carrying body nanoparticle is obtained to carry the cRGD peptide targeted doxorubicin thermosensitive liposome; (4) IR780 solution is added to the biotinylated lipid microbubble; (5) first take the IR780-loaded lipid microbubble Add avidin to the vesicles for incubation, and then add cRGD peptide targeting doxorubicin thermosensitive liposomes to obtain the double-responsive liposome-microbubble complex. The compound obtained by the method can not only reduce the loss of doxorubicin in the circulation, but also make the doxorubicin be concentrated in the center of the tumor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111249471-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113144172-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114632071-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115006368-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115006368-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110859971-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115040526-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113144172-A |
| priorityDate |
2019-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |