http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205214-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-408 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-408 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 |
| filingDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111205214-B |
| titleOfInvention | A stable isotope labeling reagent and its preparation method and application |
| abstract | The invention discloses a stable isotope labeling reagent, which is a derivative stable isotope labeling reagent containing a primary amino group and a carboxyl compound. The preparation of this reagent is to first react compounds with a primary amino group and a carboxyl group containing different stable isotopes with acetaldehyde, so that the primary amino group in the compound becomes a secondary amino group. After the product was purified by column chromatography, it was incubated with water containing 18 O or 16 O. The product is then reacted with formaldehyde containing different stable isotopes in a buffer containing sodium borohydride to change the secondary amine groups in the product into tertiary amine groups. The stable isotope labeling reagent of the invention can be applied to mass spectrometry quantitative analysis of substances with amino groups, and has the advantages of high quantitative accuracy, simple operation, low cost, and adjustable molecular weight of the quantitative reporter group, and is suitable for the quantitative analysis of amino groups. Label quantification of substances in various mass spectrometers. |
| priorityDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.