http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107556268-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-24 |
| filingDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2988fa96559ea6987aba85803d50a4c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ce0cab3769b41617fb7679b2fd4a61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b44db1a314527fc9071d706200a1937a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aaa62cd232647538545704cabba5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a9201318cb58d39109bc7e09189eb52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95a0a4f1cea72aa8439025a27f325066 |
| publicationDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107556268-A |
| titleOfInvention | A group of isotope labeling reagents for amino/phenolic hydroxyl labeling and its synthesis method |
| abstract | The invention relates to a group of isotope labeling reagents for amino/phenolic hydroxyl labeling and a synthesis method thereof. In the synthesis process, the reagents with both amino and carboxyl groups (such as the homologue of 6-aminocaproic acid) are used as raw materials, and the amino groups are converted into quaternary ammonium by reacting with methyl iodide or formaldehyde substituted with isotope D or 13 C, and Realize the isotope on methyl iodide or formaldehyde is introduced on the methyl group of quaternary ammonium. A series of products with different isotope substitutions can be obtained by selecting methyl iodide and formaldehyde with different D substitutions or 13 C substitutions and adjusting the reaction route. The series of products are further reacted with N-hydroxysuccinimide, so that the carboxyl group reacts with the hydroxyl group of N-hydroxysuccinimide to form an ester, and a group of isotope labeling reagents that can efficiently react with amino groups or phenolic hydroxyl groups are obtained. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205214-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112358446-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111205214-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112358446-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109111389-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111100024-A |
| priorityDate | 2017-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103917637-A |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465317457 |
Total number of triples: 24.