http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110951091-B

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filingDate 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110951091-B
titleOfInvention Preparation method of double-sensitive slow-release beta-cyclodextrin hydrogel
abstract The invention discloses a preparation method of double-sensitive slow-release beta-cyclodextrin hydrogel. The derivative and diethanol amine are subjected to amidation reaction to obtain the functionalized beta-cyclodextrin derivative. Reacting the functionalized beta-cyclodextrin derivative, cholic acid and epichlorohydrin in a sodium hydroxide aqueous solution to obtain a beta-cyclodextrin polymer. The beta-cyclodextrin hydrogel is synthesized by redox free radical polymerization of a beta-cyclodextrin polymer, N-isopropyl acrylamide and an acrylic acid monomer by taking ammonium persulfate as an oxidant, sodium sulfite as a reducing agent, N, N-methylene bisacrylamide as a cross-linking agent and distilled water as a solvent. The invention successfully prepares the double-sensitive slow-release hydrogel which has better temperature and pH sensitivity and slow-release performance.
priorityDate 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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