| abstract |
The present invention relates to a kind of oxazolidinone compound impurity 5-chloro-nitrogen-[[(5S)-2-oxo-3-[4-acetamidophenyl]-1,3-oxo in rivaroxaban oxazolidine-5-yl]methyl]thiophene-2-carboxamide (formula I), the impurity is 4-aminoacetanilide (formula II) and (S)-N-glycidyl phthalimide The amine (formula III) is used as the raw material, and is obtained through ring-opening coupling, ring-closing, deprotection and condensation reactions. Formula I can be applied to the quality control of rivaroxaban API, qualitative and quantitative research and detection of impurities. |