http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110652597-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6939 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 |
| filingDate | 2019-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110652597-B |
| titleOfInvention | Application of chitosan nano-scale ultrasonic contrast agent and Dickkopf-2 gene in preparation of medicine for treating prostatic cancer |
| abstract | The invention relates to an application of a chitosan nano-scale ultrasonic contrast agent and a Dickkopf-2 gene in preparation of a medicament for treating prostatic cancer. The invention discovers the relationship between the Dickkopf-2 gene and prostate cancer for the first time, obviously reduces the expression of the Dickkopf-2 gene in tissues of prostate cancer patients, takes a chitosan nano-grade ultrasonic contrast agent as a transfer vector, directionally conveys the Dickkopf-2 gene into tumor tissues, and inhibits the proliferation of tumor cells through the expression of the Dickkopf-2 gene. The chitosan nano-scale ultrasonic contrast agent prepared by the invention takes chitosan as a shell membrane material, is safe and nontoxic, has good biocompatibility and lower cost, has a particle size in a nano-scale range, can smoothly pass through the gaps of the vascular walls of tumor tissues, transmits target genes to the tumor tissues, and can be combined with an ultrasonic targeted microbubble destruction technology to obviously improve the gene transfection efficiency. |
| priorityDate | 2019-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.