| abstract |
The invention relates to a chitosan nanometer ultrasonic contrast agent carrying doxorubicin and a preparation method and application thereof, and the chitosan nanometer ultrasonic contrast agent carrying doxorubicin prepared by the invention is chitosan For the shell membrane, doxorubicin (DOX) and perfluoropropane gas are encapsulated inside the chitosan shell membrane, the particle size is 300-900 nm, the average particle size is 641 nm (polymer dispersion index PDI: 0.256), in the nanometer range It can pass through the blood vessel wall gap of tumor tissue and is targeted and efficient for the treatment of tumors. The nanometer-sized ultrasonic contrast agent has strong enhanced imaging ability, and can maintain development for a long period of time, and has high drug encapsulation rate and drug loading amount, high biosafety, and combined ultrasonic targeted destruction. Microbubbles (UTMD) can significantly improve the extraction rate of DOX and reduce the survival rate of tumor cells, which is conducive to the treatment of tumor diseases. |