| abstract |
The invention relates to a method for realizing a bicyclization reaction between a 1,6-enyne compound and a ketone compound through two ketone α-C(sp 3 )-H bond oxidations in a catalyst-free and alkali-free system. In the method, 1,6-enyne compound, ketone compound and oxidant are added into Schlenk reaction flask, and the reaction is stirred under certain temperature and air atmosphere to obtain bicyclized product. |