| abstract |
The invention relates to poly(2-cyanoacrylic acid), a preparation method and application thereof, and belongs to the field of medicine and chemical industry. First, prepare the α-cyanoacrylate polymer, and then selectively hydrolyze the ester bond of the polymer under alkaline conditions to obtain poly(2-cyanoacrylic acid). Dispersing poly(2-cyanoacrylic acid) in water to form negatively charged microspheres, a novel blank plugging microsphere is obtained, the particle size of which can be adjusted in the range of micrometers, and has the function of deformation to pass through a specific form of microspheres. Blood vessels can be tightly embolized to avoid ectopic embolism caused by shedding. Combining blank embolization microspheres with positively charged drugs, a new type of drug-loaded embolization microspheres is obtained, which adopts the principle of charge inversion, and uses the carboxyl groups of polymers to actively load positively charged drugs, which can directly localize the diseased tissue. The drug is released, and the drug rarely flows throughout the body, thereby improving the local curative effect of the drug on the diseased tissue and reducing the toxic and side effects of the drug on the whole body. |