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filingDate 2019-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_714c9280c75a159ab1f6989a172c8a55
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publicationDate 2019-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-110511974-A
titleOfInvention A kind of fermentation method that improves erythromycin fermentation titer
abstract The invention relates to a fermentation method for increasing the fermentative titer of erythromycin. The fermentation method adopts Streptomyces rubrum as the fermentation strain and is produced in a two-stage fermentation mode consisting of seed culture and fermentation culture. And the formula structure of the fermentation medium eliminates the use of soybean cake powder, adds sodium nitrate solution as a nitrogen source, and introduces the trace element cobalt, which improves the oxygen supply conditions during the fermentation process and reduces the energy consumption of oxygen supply. Enhance the vigor of bacteria, prolong the secretion period of erythromycin, and improve the fermentation level of erythromycin.
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