http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110452188-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_13db2fcac337652adaab19b1de8b830d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 |
| filingDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26cff482fb4e4e889fd25ee3955302ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2abd7986f241044359d2883f8cc85adb |
| publicationDate | 2019-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110452188-A |
| titleOfInvention | A kind of preparation method of vortioxetine |
| abstract | The invention discloses a preparation method of vortioxetine. The benzothiazole derivative (II) is dissociated into o-aminothiophenol (III) under alkaline conditions, and then reacted with the vortioxetine under the catalysis of copper or copper salt. The reaction of 2,4-dimethylhalogenated benzene to 2-(2,4-dimethylphenylsulfanyl)aniline (V), 2-(2,4-dimethylphenylsulfanyl)aniline (V) and bis(2-hydroxybenzenesulfonic acid)-4-methylbenzenesulfonic acid amide (VI) cyclization to obtain Ts-protected vortioxetine (VII), Ts-protected vortioxetine (VII) in Vortioxetine (I) is obtained under the effect of Mg. The synthesis method has easy-to-obtain raw materials, simple process, low cost, high purity and is suitable for industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210142280-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115536610-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115611788-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102508412-B1 |
| priorityDate | 2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.