| abstract |
The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound, which has excellent activity against Mycobacterium tuberculosis, multidrug-resistant Mycobacterium tuberculosis and atypical acid-fast bacillus Bactericidal effect. Specifically, the present invention provides a compound represented by formula (1) or a salt thereof, wherein R 1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzazepanyl, benzo Oxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolinyl, phenyl, biphenyl or pyridyl, these groups are optionally substituted, represented by R The phenyl, biphenyl and pyridyl groups in are each substituted directly or via a linker by at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazepanyl Alkyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctyl, oxazolyl, piperazinyl, piperidinyl, thiazolyl, etc., each of these groups is optionally substituted; and R 2 represents hydrogen or lower alkyl. The present invention also provides pharmaceutical compositions comprising the above compounds. |