| abstract |
The invention discloses a photodynamic and photothermal combined nano-therapeutic agent and its preparation method and application. The therapeutic agent includes mesoporous hollow Prussian blue as a carrier and a photothermal reagent, a free radical as a photodynamic reagent and has a photosensitive function Initiator, the free radical initiator is loaded into the inner channel of the mesoporous hollow Prussian blue, and the free radical initiator is encapsulated in the channel by a phase inversion material. The invention has simple preparation process, low cost and good biocompatibility. It has strong absorption of near-infrared light, high photothermal conversion efficiency and high free radical generation rate, deeper tumor tissue light penetration, no dependence on oxygen, and has important application prospects in tumor treatment . |