| abstract |
The present invention provides a kind of preparation method of gliquidone intermediate, traditional two-step process is substituted using one-step method, with 7- methoxyl group -2,4,4- trimethyl -1,3 (2H, 4H)-isoquinolin diketone is starting material, with the addition in the xylene solution of sodium hydroxide of 4- (2- aminoethyl)-benzsulfamide, to directly generate 4- (2- (3, methoxyl group -4 4- dihydro -7-, -2 (1H)-isoquinolyl of 4 '-dimethyl -1,3- dioxy) ethyl) benzsulfamide；The reversible reaction in two-step method is avoided, product production rate is significantly improved, in addition reaction process low dose adds sodium hydroxide, and the output of alkali waste water is greatly reduced, avoids pollution environment. |