| abstract |
The present invention relates to novel substituted N-(3-fluoropropyl)-pyrrolidine compounds of formula (I-A): wherein R1 and R2 independently represent a hydrogen or deuterium atom; A represents an oxygen or nitrogen atom; and SERM‑F represents selective estrogen receptor modulation comprising an aryl or heteroaryl group attached to the adjacent "A" group agent fragment. The present invention also relates to the preparation of compounds of formula (I-A) and their therapeutic use as estrogen receptor inhibitors and degraders. |