http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593066-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109593066-B |
| titleOfInvention | Folic acid antagonist for treating intestinal bacterial infection and preparation and application thereof |
| abstract | The invention relates to a folic acid antagonist for treating intestinal bacterial infection and a preparation method and an application thereof, the folic acid antagonist is a compound or a salt of the compound of formula I, wherein R is 1 Is H, CH 3 、CH 2 CH 3 Or CH (CH) 3 ) 2 ，R 2 Is an aromatic group, n is 1 or 2; the preparation method comprises the following steps: 1)2, 6-dimethyl quinazoline-4 (3H) -ketone is prepared from 2-amino-5-methyl benzoic acid; 2) preparing to obtain 2-methyl-6-bromomethyl quinazoline-4 (3H) -ketone; 3) preparing a folic acid antagonist; the folic acid antagonist is used for preparing medicines for treating intestinal bacterial infection. Compared with the prior art, the invention has the characteristics of effectively inhibiting the growth of bacteria, not strongly sterilizing, and low bioavailability, can be used for treating intestinal bacterial infection, and effectively avoids endotoxin harm caused by clinical use of antibiotics. |
| priorityDate | 2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.