http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105111197-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36753a15d2838b5d77ae40e8f9166011 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67d71253cac6bd41eb28c764c1513ffa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f8ccd0ded03de20c38975efa645c036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a60a758903312aca7fe62a98bba057b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_219c1c1ce14f7fa012c739c448b5229d |
| publicationDate | 2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105111197-A |
| titleOfInvention | The synthetic method of raltitrexed |
| abstract | The present invention provides two methods for preparing the compound of formula 4. Scheme 1 uses methyl 5-bromothiophene-2-carboxylate as raw material, and 6-((methylamino)methyl)-3,4-dihydro-2- Methyl-4-oxo-6-quinazoline (compound 1) reacts to obtain 2-[N-(2-methyl-4-oxoquinazoline-6-methyl)-N-methyl]- Aminothiophene-2-methyl carboxylate, then hydrolyzed in an aqueous alkali solution, and then react with L-diethyl glutamate to obtain the compound of formula 4 through condensation reaction; scheme two takes 5-bromothiophene-2-formic acid as raw material and N-(5-bromothien-2-yl) diethyl glutamate is obtained through condensation of L-glutamic acid diester, and then reacted with a compound of formula 1 to obtain a compound of formula 4; the present invention also provides a preparation In the method of raltitrexed, the compound of formula 4 is hydrolyzed in an aqueous alkali solution, and then acidified with hydrochloric acid to prepare raltitrexed. The synthesis route adopted by the invention has few reaction steps, simple and convenient operation, little environmental pollution and high product yield. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106957311-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106957311-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110551114-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106957312-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593066-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106957312-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109593066-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107129492-A |
| priorityDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010039792-A1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465755394 |
Total number of triples: 24.