http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109553513-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-178 |
| filingDate | 2019-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109553513-B |
| titleOfInvention | Preparation method of metoprolol intermediate |
| abstract | The invention belongs to the field of organic synthesis of medicines, and particularly relates to a preparation method of an intermediate of a medicine metoprolol for treating hypertension. The synthetic route provided by the invention is as follows: p-bromophenol reacts with methyl vinyl ether in the presence of a palladium catalyst and a phosphine ligand to generate 4- (2-methoxyvinyl) phenol; hydrogenating 4- (2-methoxyvinyl) phenol in the presence of a palladium-carbon catalyst to obtain a target product 4- (2-methoxyethyl) phenol. The method has the advantages of short reaction steps, cheap and easily-obtained raw materials, simple process, convenient operation and no need of special reaction conditions, thereby being more suitable for industrial production. |
| priorityDate | 2018-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.