| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db9efde660b78f98b102046e09d07ab7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-48 |
| filingDate |
2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fc2f210d80e90290186de00f27b5fca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34280c2d3344644578dc386eb16f967e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e00f8986e94fb5bd0b2f169657e2c23d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2e385ab26a85465428b07b490fffc1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e89e04bcd12306ff6c36f77c2e233066
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96c2ae1da3a153b69f32e48d2432269c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f6cd2bb547adafdc6ac56902a9fb6d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_486a34a8ad0d29878193c79cc3458782
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ad3ec0d3f179a5e353c756b7ac31549 |
| publicationDate |
2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109270154-A |
| titleOfInvention |
DNA tetrahedron-based solid-state nanopore single-molecule protein detection signal amplification method and DNA tetrahedron |
| abstract |
The invention discloses a solid-state nanopore single-molecule protein detection signal amplification method based on DNA tetrahedron and a DNA tetrahedron used thereby. The method of the present invention comprises: preparing a DNA tetrahedron having a three-dimensional structure: the DNA tetrahedron is synthesized by hybridization of four nucleic acid tiles, the nucleic acid tile being composed of a first single-stranded nucleic acid, a second single-stranded nucleic acid, The third single-stranded nucleic acid hybridization synthesis; the DNA tetrahedron is connected with the protein molecule to be tested; the solid nanopore detection platform is used for detection; the invention overcomes the defect that the single-molecular protein is too fast in the detection of the nanopore sensor, and increases The signal-to-noise ratio of the signal is detected to overcome the occurrence of protein agglomeration during the detection process, the sample consumption is small, and the detection sensitivity is high. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111879941-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111521785-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111825734-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112147185-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112147185-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110954445-A |
| priorityDate |
2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |