| abstract |
The invention discloses a cisplatin drug prodrug, its preparation method and application. The structural formula of the cisplatin drug prodrug is as formula (I), which is produced by the esterification reaction between activated dihydroxy cisplatin and hydrophobic molecules of. The characterization of nano-preparations shows that the nanoparticles in the present invention are evenly distributed, about 30nm, by dynamic light scattering and transmission electron microscopy; in vitro cytotoxicity experiments show that the nano-medicines can significantly inhibit the proliferation of tumor cells (A549 and LoVo); in vivo experiments show , compared with cisplatin injection, on the basis of reducing systemic toxicity, it has the effect of inhibiting non-small cell lung cancer A549 subcutaneous tumor, and has a good market prospect and clinical application value. |