http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020972-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 |
| filingDate | 2018-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109020972-B |
| titleOfInvention | Preparation method of triazolo [1,5-a ] quinoline derivative |
| abstract | The invention discloses a preparation method of a triazolo [1,5-a ] quinoline derivative. The preparation method comprises the steps of adding o-triazole substituted bromobenzene, 1, 2-disubstituted acetylene, a catalyst, a ligand and weak base into an organic solvent to form a uniform reaction system, performing addition cyclization, and separating and purifying to obtain the triazolo [1,5-a ] quinoline derivative. According to the invention, o-triazole substituted bromobenzene and disubstituted acetylene are used as raw materials, a quinoline ring is not required to be constructed in advance, the raw materials are simple and easy to obtain, the synthesis method has few byproducts and high yield, the yield is over 70%, and the yield of part of substrates is between 85% and 89%, so that richer compound choices can be provided for screening the drug effects of the compounds in treating mental disorders, depression, anxiety disorders, sexual dysfunction and other diseases, a high-yield route is provided for mass production of the compounds, and the method has extremely high economic value and application prospect. |
| priorityDate | 2018-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.