| abstract |
The invention discloses a new method for synthesizing 2-fluoro-1,3-dicarbonyl compounds, specifically: dispersing 1,3-dicarbonyl compounds with structure (I) and fluorine reagents with structure (II) in In the solvent, add an appropriate amount of silver catalyst to the above mixture, and react by heating to obtain a 2-fluoro-1,3-dicarbonyl compound with structure (III): The specific structure of III is: The present invention provides a 1,3-dicarbonyl compound and 1-fluoropyridine tetrafluoroborate as the starting raw materials for the reaction, through the mechanism of silver-catalyzed single-ton electron transfer to synthesize the target 2-fluoro-1, A new approach to 3‑dicarbonyl compounds. The method has a wide range of substrates, and various 2-fluoro-1,3-dicarbonyl compounds can be constructed. The method involves mild reaction conditions, simple operation, product diversity, and large-scale production. |