| abstract |
The invention provides a preparation method of Ozamod and its intermediate. The method of the present invention uses 2,3-dihydro-4-cyano-1-indanone as a raw material to prepare compound III through a suitable method. Protecting the amino group and hydroxyl group of compound III with a protecting agent to prepare compound IV. Compound IV is salt-treated to obtain compound V. The compound VII is obtained by carrying out a ring closure reaction between the compound V and the compound VI. Ozamod was prepared by deprotecting compound VII. Compared with the traditional method, the method of the present invention reduces the reaction steps, improves the total yield, and produces high-quality products; the reaction conditions are mild, and the application of dangerous operating conditions, highly toxic reagents and expensive chemical reagents is avoided, and the traditional method is not only solved The security problems existing in the method, and the cost is reduced, so it is suitable for industrialized production. |