abstract |
The present invention provides compounds that selectively modulate sphingosine-1-phosphate receptors, including compounds that modulate S1P receptor subtype 1. The present invention provides methods for the chiral synthesis of such compounds. The present invention also provides uses of compositions comprising compounds of the present invention, methods of treatment or prevention and methods of preparation associated with the treatment or prevention of diseases, conditions or disorders medically requiring modulation of sphingosine 1 -phosphate receptors. |