| abstract |
The present invention relates to RNA interference-mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acids (siNA). The present invention also relates to compounds, compositions and methods for the study, diagnosis and treatment of traits, diseases or conditions that respond to modulation of HBV gene expression and/or activity and/or modulate HBV gene expression pathways. In particular, the present invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded Stranded RNA (dsRNA), microRNA (miRNA) and short hairpin RNA (shRNA) molecules. |