| abstract |
The invention discloses a new application of 2,4-dinitrobenzenesulfonamide compounds, that is, the use of 2,4-dinitrobenzenesulfonamide compounds for the preparation of thioredoxin reductase inhibitors. It is a compound with the following general structural formula or a pharmaceutically acceptable salt thereof: Among them, A is a ring with 3 to 10 members; R is hydrogen, substituted or unsubstituted aliphatic hydrocarbon group, substituted or unsubstituted alicyclic hydrocarbon group, substituted or unsubstituted aliphatic heterocyclic hydrocarbon group, substituted or unsubstituted aryl group, substituted or unsubstituted heteroaryl; R 1 is a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted alicyclic hydrocarbon group, a substituted or unsubstituted aliphatic heterocyclic hydrocarbon group, a substituted or unsubstituted aryl group, a substituted or unsubstituted The heteroaryl. The invention can provide a new strategy for cancer targeted therapy. |