| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f9ea6621079cc7a2f96c3fd454e2a86 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3521
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a7fe8fce720fd2d1c76f2f0beebadeb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b40867c6c70b6145c06ca0a20570aff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ccb5eb5709377a63e1122373d9e6511 |
| publicationDate |
2018-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108291225-A |
| titleOfInvention |
Use of single-stranded antisense oligonucleotides in the prevention or treatment of genetic diseases involving trinucleotide repeat expansion |
| abstract |
The present invention relates to antisense oligonucleotides (AON) comprising repeating trinucleotide units for the treatment or prevention of hereditary eye diseases, preferably ocular dystrophies caused by RNA toxicity such as Fuchs endothelial corneal dystrophy (FECD) . The oligonucleotides of the invention are used to target expansions of trinucleotide repeat (TNR) sequences present in intronic sequences to prevent disease-associated sequestration of cellular proteins interacting with such TNR expansions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111849991-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113557010-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111849991-B |
| priorityDate |
2015-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |