| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7a7b5066ee171fcccd86faa674cd89c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate |
2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00abff94d00946bf4c19038cdfbcf06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d4cdda15b5741eb1a8698d0ea41419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92e57b3fb623430a6f56e8c38ad005e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f06531c5d75aa6d9ba861b08653cdd8c |
| publicationDate |
2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-107941936-A |
| titleOfInvention |
Method and application of separation and determination of rivaroxaban and its impurities |
| abstract |
The invention belongs to the field of analytical chemistry, and in particular relates to a method and application for separating and measuring rivaroxaban and its impurities. The reagent composition that is used for separating and measuring rivaroxaban and its impurity is: diluent: the aqueous solution of acetonitrile-acid; Mobile phase A: the buffered saline solution containing methanol and acetonitrile; Mobile phase B: the mixing of buffered saline solution and acetonitrile liquid. The method for the separation and determination of rivaroxaban and its impurities using the above reagent composition is as follows: take rivaroxaban and dissolve it in a diluent to obtain a sample solution; prepare a mobile phase; inject the sample solution into a separation and detection system, and use the mobile phase Carry out elution and separation relative to the sample solution to obtain an eluate; the eluate enters a detector for determination. The invention can completely separate rivaroxaban and its impurities, has good baseline, high sensitivity, short analysis time and good reproducibility, and can effectively separate and measure the contents of related substances in rivaroxaban raw materials and preparations. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110849994-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110954603-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110954603-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112903846-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110118836-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110118836-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109180668-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112557543-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116500173-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110057942-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110187023-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110849994-B |
| priorityDate |
2017-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |