| abstract |
The invention discloses an arylethyl piperidinyl derivative and its application in anti-schizophrenia. The results of pharmacological experiments show that the arylethylpiperidine compounds involved in the present invention have relatively high affinity for dopamine D 2 , D 3 , 5-HT 1A , and 5-HT 2A receptors, and are selective for D 3 /D 2 receptors. sex is good. The results of in vivo experiments show that the preferred compound has good anti-schizophrenia effect, low acute toxicity, high safety, good pharmacokinetic properties, and has development value as a new antipsychotic and neurological disease drug with high efficiency and low toxicity. The arylethylpiperidine compound is a compound having the general structural formula (I) or its salt or a hydrate of the salt: |