| abstract |
The invention discloses a piperazine (pyridine) cyclohexyl derivative and its application for treating mental and nervous diseases. The results of pharmacological experiments show that the piperazine (pyridine) cyclohexyl derivatives involved in the present invention have higher affinity to dopamine D 2 , D 3 and serotonin 5-HT 1A , 5-HT 2A receptors; to D 3 /D 2 Good selectivity for receptors, good selectivity for 5-HT 1A /5-HT 2A receptors; low affinity for α receptors. In vivo test results show that the preferred compound has good anti-schizophrenia effect, good pharmacokinetic properties, low side effects and acute toxicity, high safety, and has development value as a new type of high-efficiency and low-toxicity antipsychotic drug. The piperazine(pyridyl)cyclohexyl derivative is a compound having the general structural formula (I) or its geometric isomers, optical isomers, salts, hydrates or solvates. |