http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107759577-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b5b83b7d77784292d53fdada4b3899b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 |
| filingDate | 2017-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3a59e28d093d1fa849553dedb1497e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f88e7607c7a723b4434c094db2d8dccd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97b8df593b234073a97a0053b0434a6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13aaa6afa463df3f43ced1886e721a98 |
| publicationDate | 2018-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107759577-A |
| titleOfInvention | GS5816 intermediate, preparation method and application |
| abstract | The invention discloses a GS5816 intermediate, a preparation method and an application. The present invention provides a preparation method of compound 12, comprising the following steps: performing condensation reaction of compound 13 and compound 9 in an organic solvent in the presence of a condensing agent to obtain compound 12. The preparation method of the present invention has mild reaction conditions, simple and safe operation, no need for special purification equipment, avoids column chromatography separation operation in the post-treatment process, and is easy to control chiral isomers. The yield of patasvir is high, the chemical and optical purity of the prepared velpatasvir is greater than 99.50%, and all impurities are less than 0.10%, which can meet the standard of raw materials, has low cost, and is suitable for industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111018870-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111018870-A |
| priorityDate | 2016-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.