abstract |
The present invention provides a new synthesis method for the hepatitis C drug velpatasvir, which uses two intermediate compounds 4 and compound III to synthesize velpatasvir. The structures of the two compounds are as follows: Among them, the PG group is tert-butoxycarbonyl (Boc), benzyloxycarbonyl (Cbz), acetyl, benzoyl or (S)-2-methoxycarbonylamino-3-methyl-butyryl (Moc- L-Valyl). |