http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107304205-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-04 |
| filingDate | 2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107304205-B |
| titleOfInvention | A kind of maraviro intermediate and preparation method thereof |
| abstract | The invention discloses a maraviroc intermediate and a preparation method thereof. Described structure is the preparation method of the intermediate of maraviroc shown in formula 2, described method comprises steps: (1) make 3-chloropropiophenone and 3-(3-isopropyl-5-methyl- 4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane reaction obtains the compound whose structure is shown in formula 5; (2) makes the structure shown in formula 5 The compound is reacted with the chiral auxiliary (S)-tert-butyl sulfinamide to generate the compound whose structure is shown in formula 4; (3) the compound whose structure is shown in formula 4 is reduced to obtain the compound whose structure is shown in formula 3; (4) (S)-3-((3-isopropyl-5-methyl-4H-1,2,4-triazole-4-yl) obtained by hydrolysis of the compound shown in formula 3 -8-azabicyclo[3.2.1]octane-8-yl)-1-phenylpropylamine hydrochloride is treated with an alkaline solution to obtain the compound whose structure is shown in formula 2. |
| priorityDate | 2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.