| abstract |
The present invention provides a compound of formula (I): or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF or nitrogen; and R is H or C -2 alkyl; R 1a is selected from CONH 2 ; CO 2 H; optionally substituted acyclic C 1-8 hydrocarbon groups; and optionally substituted monocyclic carbocyclic or heterocyclic ring members of 3 to 7 ring members Ring group, wherein 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S; R 2 is selected from hydrogen and group R 2a ; R 2a is selected from optionally substituted non Cyclic d-8 hydrocarbon groups; optionally substituted monocyclic carbocyclic or heterocyclic groups of 3 to 7 ring members, wherein 0, 1 or 2 ring members are heteroatoms selected from O, N and S ring members; and optionally substituted bicyclic heterocyclic groups of 9 or 10 ring members, wherein 1 or 2 ring members are nitrogen atoms; wherein at least one of R and R is not hydrogen; R is optionally Substituted 3- to 10-membered monocyclic or bicyclic carbocyclic or heterocyclic rings containing 0, 1, 2 or 3 heteroatom ring members selected from N, O and S; R is selected from halogen; cyano ; C 1-4 alkyl optionally substituted by one or more fluorine atoms; C 1-4 alkoxy optionally substituted by one or more fluorine atoms; hydroxy-C 1-4 alkyl; and C 1-2 alkoxy-C 1-4 alkyl; R 5 is selected from hydrogen and substituent R 5a ; and R 5a is selected from C 1-2 alkyl optionally substituted by one or more fluorine atoms; C 1-3 alkoxy optionally substituted by one or more fluorine atoms; halogen; cyclopropyl; cyano; The compound has anti-hepatitis C virus activity and can be used for preventing or treating hepatitis C virus infection. |