http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107043375-A

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filingDate 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccf2af47066154cc0039c51d04f4a393
publicationDate 2017-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-107043375-A
titleOfInvention A new method for preparing dasatinib and its intermediates
abstract The invention discloses a new method for preparing dasatinib and its intermediates, comprising the steps of obtaining dasatinib through substitution, hydroxymethylation, oxidative amidation, positional chlorination and amination of 2-aminothiazole (2) Ni (1). The invention has short synthesis route, high reaction yield, cheap and easy-to-obtain raw materials, greatly reduces production cost, mild reaction conditions, is suitable for industrial scale production, avoids the use of acid chlorides, and reduces environmental pollution.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108383844-A
priorityDate 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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