http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106800539-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-106800539-B |
| titleOfInvention | A kind of acotiamide hydrochloride hydrate intermediate and its synthesis technology and application |
| abstract | The present invention provides a kind of acotiamide hydrochloride hydrate intermediate and its synthesis technology and applications, belong to technical field of medicine synthesis, the synthesis technology includes the following steps: (1) by 2,4,5- trimethoxybenzoic acids, thiazolamine -4- Ethyl formate, 1- hydroxy benzo triazole, acid binding agent are mixed with organic solvent；(2) in the mixture of Xiang Suoshu step (1), diisopropylcarbodiimide is added；(3) after the completion of the step (2), the acotiamide hydrochloride hydrate intermediate is obtained controlled at 25~50 DEG C of reactions, synthesis technology of the present invention is avoided using thionyl chloride, operating environment is improved, and the reaction time is shorter, side reaction is few, purification process is simple, for optimal yield up to 68%, purity 98.8% is suitable for industrial amplification production. |
| priorityDate | 2016-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.