| abstract |
The invention relates to a preparation method of an acotiamide hydrochloride intermediate. The method uses 2,4,5-trimethoxybenzoic acid and ethyl 2-aminothiazole-4-carboxylate as starting materials, and condenses under the combined action of a condensing agent TBTU and an acid-binding agent DIEA to obtain a target product. The reaction of the invention avoids the use of strong corrosive solvents, is simple to operate, is suitable for industrial production, and has high yield and good purity. |