| abstract |
The present invention relates to the synthesis method of chiral γ-butyrolactone substituted at the 4-position shown in formula I, which has low cost and high enantioselectivity, and is widely used in the synthesis of important biologically active compounds or key drug intermediates prospect. R is selected from C1-C6 straight chain or branched chain alkyl group, C2-C8 straight chain or branched chain alkenyl group, C2-C8 straight chain or branched chain alkyne alkyl group, 3-8 membered alicyclic group, aryl group , heteroaryl, Ar(CH 2 )n-group, wherein, Ar represents aryl, heteroaryl, n=1-6. |