abstract |
The present invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and gene transfer method and application mediated by AAV-Rh74 and related AAV vectors. In particular, AAV-Rh74 and related AAV vectors target polynucleotides to cells, tissues, or organs for the expression (transcription) of genes encoding therapeutic proteins and peptides, as well as polynucleotides that serve as or are transcribed into inhibitory nucleic acid sequences. glycosides. |