| abstract |
The invention belongs to the field of medicine and chemical industry, and specifically relates to a preparation method of dapagliflozin, which uses 2,3,4,6-α-D-glucopyranose tetraacetate as a raw material, undergoes sulfonylation, nucleophilic Dapagliflozin was obtained through three reaction processes of substitution reaction and deacetylation reaction. The invention has the advantages of mild reaction conditions, simple and reasonable process flow, short reaction time, simple aftertreatment, high product quality, high yield and the like. |