| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6857
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886 |
| filingDate |
2013-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2019-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105007941-B |
| titleOfInvention |
Anti-LAMP1 antibody and antibody-drug conjugate and use thereof |
| abstract |
The present application provides antibodies that specifically bind to the human and cynomolgus monkey (Macaca fascicularis) lysosome-associated membrane protein 1 (LAMP1) protein and immunoconjugates comprising the antibodies conjugated or linked to growth inhibitors. The present application also provides pharmaceutical compositions comprising the antibodies or immunoconjugates of the present invention and uses of the antibodies or immunoconjugates for the treatment of cancer, as well as LAMP1 antibodies, isolated nucleic acids comprising sequences encoding the antibodies, vectors and host cells, and the use of the antibody as a diagnostic tool. The application further provides detection of LAMP1 gene amplification or gain in cancer cells to determine whether a patient with cancer is likely to respond to anti-LAMP1 therapy. Accordingly, an in vitro method of selecting a patient with cancer is proposed, the method comprising determining in a biological sample comprising cancer cells of a patient with cancer whether the patient contains a LAMP1 gene copy number gain; and based on the presence of the LAMP1 gene copy number gain to select patients. The application further provides anti-LAMP1 therapeutics for the treatment of cancer in a patient containing a gain in the copy number of the LAMP1 gene in cancer cells. |
| priorityDate |
2012-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |