| abstract |
The invention provides a preparation method of 3-alkenylindole compounds shown in formula (III): in a stainless steel ball mill tank, add N-substituted indole compounds shown in raw material formula (I) and formula (II ) shown in the olefin compound, catalyst palladium acetate, oxidant manganese dioxide, grinding aid silica gel, grinding media stainless steel balls, sealed ball milling tank, placed in the ball mill with a speed of 100 to 650r/min for ball milling reaction for 20 to 75 minutes, The reaction mixture is separated and purified to obtain the 3-alkenylindole compound shown in formula (III); the method of the present invention effectively applies the mechanical grinding technology to the oxidation Heck coupling reaction for the first time to prepare the 3-alkenylindole Compounds and substrates have a wide range of applications, are cost-effective and environmentally friendly. |