http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104072565-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2014-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104072565-B |
| titleOfInvention | A kind of simple preparation method of 17 α hydroxyl progesterones of high yield |
| abstract | The present invention relates to a kind of simple preparation method of 17 α hydroxyl progesterones of high yield.The method, with 4 androstenedione as initial feed, to 17 carbonyls of 4 androstenedione by carrying out cyanohydrination additive reaction with acetone hydrogen alcohol, obtains 17 α hydroxyl, 17 β cyano group androstane-14 alkene 3 ketone, then C3 position carbonyl is carried out with ketal protection reaction, obtains ketal product；By this ketal product, directly and zinc chloride methane carries out methylation reaction, then hydrolyzes to obtain 17 α hydroxyl progesterones；Present invention process flow process is short, high income, product purity high；Reaction condition is gentle, with low cost, energy consumption is low, is particularly well-suited to industrialized production. |
| priorityDate | 2014-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.