| abstract |
The invention discloses a synthesis method of 17α-hydroxyprogesterone, which uses 4-androstene-dione as a starting material, undergoes cyanation with acetone cyanohydrin, protects the 3-position carbonyl with triethyl orthoformate and ethanol, and uses Vinyl butyl ether protects the 17-hydroxyl group, and after Grignard reaction, it is hydrolyzed to generate 17α-hydroxy progesterone. The invention can reduce cost, reduce environmental pollution, shorten reaction time, simplify industrial production post-treatment process, greatly save production time and cost, increase production capacity, and facilitate industrial implementation. Compared with the traditional process, the present invention has the characteristics of low raw material cost, simple and convenient method, high yield, good selectivity, mild reaction conditions, little pollution, applicable to industrialized production, stable method and easy realization. |