abstract |
The present invention relates to a method and composition for inhibiting trimerization of ligands belonging to the TNF superfamily. In particular, the invention relates to the inhibition of trimerization of RANKL. Accordingly, the methods and compositions provided herein can be used to treat disorders associated with increased RANK signaling, in particular, disorders involving bone loss. Novel compounds that inhibit trimerization of ligands belonging to the TNF superfamily are also provided. |