http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103910669-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 |
| filingDate | 2014-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103910669-B |
| titleOfInvention | The preparation method of BMS-477118 key intermediate |
| abstract | The invention discloses the preparation method of BMS-477118 key intermediate, in aprotic solvent, under alkali effect, unpurified compound V is closed ring and obtain key intermediate VI, key intermediate VI tin extraction excessively, washing, flash column chromatography obtain, temperature of reaction is-10 °-100 °, reaction times is 1-10h, alkali: the mass ratio of compound V is 0.5-5:1.Wherein, compound V is:n ; Compound VI is:n ; Rn 1 for methyl, ethyl, the tertiary butyl, (1R, 2S, 5R)-2-sec.-propyl-5-methyl-cyclohexyl base; Rn 2 for the tertiary butyl, benzyl, X is Cl, OMs, OTs.Advantage is: in the present invention, compound V does not need purifying, substantially reduces finishing time, and operate more simple and convenient, realize large-scale production than being easier to, reactions steps is few, and yield is high. |
| priorityDate | 2014-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.