| abstract |
The invention provides a method for producing saxagliptin, the steps comprising: step 1, providing compound d; step 2, reacting compound d, isopropanol and concentrated hydrochloric acid at 50-80°C, collecting the product to obtain saxagliptin Littin. Compared with the prior art, the present invention directly converts the compound d into the target product, thereby greatly improving the reaction rate, increasing the reaction yield, simplifying the post-treatment method, and greatly reducing the generation of industrial wastewater. |